Profile: BioSpectra, Inc. deals with the manufacturing of buffers. Our product portfolio includes guanidine hydrochloride, tris hydrochloride, tromethamine, U.S.P, and urea. The guanidine hydrochloride is a chaotropic agent used to disrupt the structure of proteins. Being a denaturant, it acts to unfold proteins and turns them into their original polypeptide chains. It is commonly utilized in the isolation of RNA by dissociating the RNA into its nucleic acids and protein forms. It decreases enzyme activity when used in higher concentrations. It is also used to increase the solubility of hydrophobic molecules. The Urea U.S.P is commonly utilized in denaturing and solubilizing proteins. It is used to restructure proteins, being a chaotropic agent. In certain cases where proteins are denatured, it may also be useful in renaturing these proteins.