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Profile: Sigma-Aldrich Inc. supplies building blocks and reagents for synthesis in organic and inorganic chemistry. We offer functionalized heterocycles for medicinal applications & syntheses of advanced organic intermediates. Our chiral line includes auxiliaries, enzymes, and reagents for resolution techniques, biotransformations, and enantioselective catalysis.

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• Palladium(Ii) Nitrate Hydrate

IUPAC Name: palladium(2+);dinitrate;hydrate | CAS Registry Number: 82279-70-7
Synonyms: Palladium(II) nitrate hydrate, AG-F-04151, 207596-32-5, ACMC-1BNAE, Palladium nitrate hydrate, Palladous nitrate hydrate, Palladium dinitrate hydrate, KSC492S0R, 205761_ALDRICH, CTK3J2908, AKOS015855141, PALLADIUM(II) NITRATE HYDRATE;PALLADIUM NITRATE HYDRATE, 313222-87-6

Molecular Formula:	H₂N₂O₇Pd	Molecular Weight:	248.445080 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	7

InChIKey: DTZRLFJKQHIVQA-UHFFFAOYSA-N

• Palladium(Ii)[1,3-Bis(Diphenylphosphino)Propane]-Bis(Benzonitrile)-Bis-Tetrafluoroborate

IUPAC Name: benzonitrile;3-diphenylphosphanylpropyl(diphenyl)phosphane;palladium(2+);ditetrafluoroborate | CAS Registry Number: 175079-12-6
Synonyms: [Pd(dppp)(PhCN)2](BF4)2, Palladium(II)[1,3-bis(diphenylphosphino)propane]-bis(benzonitrile)-bis-tetrafluoroborate, SC10535

Molecular Formula:	C₄₁H₃₆B₂F₈N₂P₂Pd	Molecular Weight:	898.714690 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	12

InChIKey: VCESXCUPOICDRS-UHFFFAOYSA-N

• Pancuronium dibromide

IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate dibromide | CAS Registry Number: 15500-66-0
Synonyms: pancuronium, Pavulon, Mioblock, PANCURONIUM BROMIDE, Pavulon (TN), ORG NA 97, HSDB 3244, Pancuronii bromidum [INN-Latin], P1918_SIGMA, Bromure de pancuronium [INN-French], Bromuro de pancuronio [INN-Spanish], NA 97, EINECS 239-532-5, C35H60N2O4, NSC 293162, Pancuronium bromide [USAN:BAN:INN:JAN], DB01337, Pancuronium bromide (JP15/USAN/INN), LS-116480, EU-0100887

Molecular Formula:	C₃₅H₆₀Br₂N₂O₄	Molecular Weight:	732.669900 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	6

InChIKey: NPIJXCQZLFKBMV-YTGGZNJNSA-L

• Para Xylene

IUPAC Name: 1,4-dimethylbenzene | CAS Registry Number: 106-42-3
Synonyms: P-XYLENE, p-Methyltoluene, 1,4-Dimethylbenzene, p-Dimethylbenzene, Para-Xylene, p-Xylol, Scintillar, Chromar, 1,4-Xylene, 4-Xylene, Dimethylbenzene, Benzene, 1,4-dimethyl-, Solvent xylene, Xylene, p-isomer, 4-Methyltoluene, p-Xylenes, Xylene, p-, Benzene, p-dimethyl-, 1,4-Dimethylbenzol, CCRIS 910

Molecular Formula:	C₈H₁₀	Molecular Weight:	106.165000 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	0

InChIKey: URLKBWYHVLBVBO-UHFFFAOYSA-N

• Paraldehyde

IUPAC Name: 2,4,6-trimethyl-1,3,5-trioxane | CAS Registry Number: 123-63-7
Synonyms: PARALDEHYDE, Paracetaldehyde, Paral, Elaldehyde, Paraldehyd, Paraacetaldehyde, p-Acetaldehyde, Acetaldehyde trimer, Triacetaldehyde, Paraldeide, Acetaldehyde, trimer, Paraldehyd [German], Paraldehyde [USAN], Paraldeide [Italian], Paraldehyde (USP), s-Trimethyltrioxymethylene, PCHO, Paral (TN), Triacetaldehyde [French], 2,4,6-Trimethyl-s-trioxane

Molecular Formula:	C₆H₁₂O₃	Molecular Weight:	132.157680 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	3

InChIKey: SQYNKIJPMDEDEG-UHFFFAOYSA-N

• Pea Agar

• Pefloxacin Mesylate Dihydrate

IUPAC Name: 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid;dihydrate | CAS Registry Number: 149676-40-4
Synonyms: Pefloxacin mesylate dihydrate, Peflacine, Peflacin, UNII-CX28QC6FU0, Peflox, RB 1589, AC1OCEI3, CHEMBL2104775, MolPort-002-339-583, BB_SC-0192, Pefloxacin mesylate dihydrate [EP], AKOS015896973, KS-1095, Pefloxacinium methanesulfonate dihydrate, Pefloxacine monomethanesulfonate dihydrate, A836889, I06-2533, S4119,149676-40-4, 1-ethyl-6-fluoranyl-7-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinoline-3-carboxylic acid; methanesulfonic acid; dihydrate, 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; methanesulfonic acid; dihydrate

Molecular Formula:	C₁₈H₂₈FN₃O₈S	Molecular Weight:	465.493623 [g/mol]
H-Bond Donor:	4	H-Bond Acceptor:	12

InChIKey: LEULAXMUNMRLPW-UHFFFAOYSA-N

• PEG-8 dioleate

IUPAC Name: 2-[(Z)-octadec-9-enoyl]oxyethyl (Z)-octadec-9-enoate | CAS Registry Number: 9005-07-6
Synonyms: Poly(oxy-1,2-ethanediyl), .alpha.-[(9Z)-1-oxo-9-octadecenyl]-.omega.-[[(9Z)-1-oxo-9-octadecenyl]oxy]-

Molecular Formula:	C₃₈H₇₀O₄	Molecular Weight:	590.960000 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	4

InChIKey: NKSOSPOXQKNIKJ-CLFAGFIQSA-N

• Pentaammine(Dinitrogen)Osmium(Ii) Chloride

IUPAC Name: azane;dichloroosmium;molecular nitrogen | CAS Registry Number: 20611-50-1

Molecular Formula:	Cl₂H₁₅N₇Os	Molecular Weight:	374.302000 [g/mol]
H-Bond Donor:	5	H-Bond Acceptor:	7

InChIKey: SBZRXJDJGVUVPV-UHFFFAOYSA-L

• Pentaammine(Trifluoromethanesulfonato)Osmium(Iii) Triflate

IUPAC Name: azane;osmium;trifluoromethanesulfonate | CAS Registry Number: 83781-30-0
Synonyms: Pentaammine(trifluoromethanesulfonato)osmium(III) triflate, Pentaammine(trifluoromethanesulfonato)osmium(III) trifluoromethanesulfonate

Molecular Formula:	C₃H₁₅F₉N₅O₉OsS₃-₃	Molecular Weight:	722.589929 [g/mol]
H-Bond Donor:	5	H-Bond Acceptor:	23

InChIKey: KJOSOZBKYCOBQT-UHFFFAOYSA-K

• Pentafluorobenzoyl chloride

IUPAC Name: 2,3,4,5,6-pentafluorobenzoyl chloride | CAS Registry Number: 2251-50-5
Synonyms: Perfluorobenzoyl chloride, P0782_SIGMA, 103772_ALDRICH, 2,3,4,5,6-Pentafluorobenzoyl chloride, Pentafluorobenzoic acid chloride, 76732_FLUKA, CHEBI:39425, NSC97002, EINECS 218-842-4, NSC 97002, ZINC01627117, AC 14712, P140, 67924-15-6

Molecular Formula:	C₇ClF₅O	Molecular Weight:	230.519316 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	6

InChIKey: MYHOHFDYWMPGJY-UHFFFAOYSA-N

• Pentamethylcyclopentadienylrhodium(Iii) Chloride Dimmer

IUPAC Name: dichlororhodium(1+);1,2,3,4,5-pentamethylcyclopenta-1,3-diene | CAS Registry Number: 12354-85-7

Molecular Formula:	C₂₀H₃₀Cl₄Rh₂	Molecular Weight:	618.075200 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	2

InChIKey: AUBQNRPCZLEJIZ-UHFFFAOYSA-J

• Pentetic Acid

IUPAC Name: 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid | CAS Registry Number: 67-43-6
Synonyms: Pentetic acid, Detapac, Complexon V, Detarex, Perma kleer, Penthanil, Monaquest CAI, DTPA, Hamp-Ex Acid, Titriplex V, Monaquest, Penthamil, Dabeersen 503, Dissolvine D, Pentetates, Pentacin, Pentacine, Pentaind, Penthamil (VAN), CHEL 330 acid

Molecular Formula:	C₁₄H₂₃N₃O₁₀	Molecular Weight:	393.346520 [g/mol]
H-Bond Donor:	5	H-Bond Acceptor:	13

InChIKey: QPCDCPDFJACHGM-UHFFFAOYSA-N

• Peptide antibodies

• Peptides

Molecular Formula:	C₄₅H₃₆Cl₄N₆O₁₀	Molecular Weight:	962.613540 [g/mol]
H-Bond Donor:	9	H-Bond Acceptor:	12

InChIKey: ITEJDHVEYLBYQP-DDFLMXQMSA-N

• Petri dish Agar

• Ph buffer solution

• Phenolphthalein Indicator

• Phenoxy Phenol

IUPAC Name: 4-(phenoxy)phenol | CAS Registry Number: 831-82-3
Synonyms: p-Phenoxyphenol, 4-PHENOXYPHENOL, Phenol, 4-phenoxy-, Phenol, p-phenoxy-, p-Hydroxydiphenyl ether, 4-Hydroxydiphenyl ether, 4-(phenyloxy)phenol, Hydroquinone monophenyl ether, Phenol, p-phenoxy- (8CI), 230669_ALDRICH, 77760_FLUKA, CHEBI:39264, EINECS 212-611-1, NSC 25027, NSC25027, ZINC00158246, LS-184899, ST5406502, AC-907/25014304

Molecular Formula:	C₁₂H₁₀O₂	Molecular Weight:	186.206600 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	2

InChIKey: ZSBDGXGICLIJGD-UHFFFAOYSA-N

• Phenyl XylylEthane

IUPAC Name: 1,2-dimethyl-4-(1-phenylethyl)benzene | CAS Registry Number: 6196-95-8
Synonyms: Phenyl xylyl ethane, 4-(1-Phenylethyl)-o-xylene, CID22570, EINECS 228-249-2, Phenyl-1-(3,4-dimethyl)phenylethane, Ethane, 1-phenyl-1-(3,4-xylyl)-, 1,2-dimethyl-4-(1-phenylethyl)benzene, 1-(3,4-Dimethylphenyl)-1-phenylethane, Benzene, 1,2-dimethyl-4-(1-phenylethyl)-, 1-PHENYL-1-(3,4-DIMETHYLPHENYL)ETHANE, 58465-67-1, 76090-67-0

Molecular Formula:	C₁₆H₁₈	Molecular Weight:	210.314120 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	0

InChIKey: FLWSNJAEMMOZJG-UHFFFAOYSA-N

• Phorbol 12-myristate 13-acetate

Synonyms: Phorbol ester, yristate, Factor A1, -yl ester, Phorbol myristate acetate, PMA (tumor promoter), Factor A1 (croton oil), nchembio.154-comp9, TPA (phorbol derivative), SpecPlus_000801, Tetradecanoylphorbol acetate, Phorbol-myristate acetate, 12-Tetradecanoylphorbol 13-acetate, Spectrum2_001911, Spectrum4_000889, Spectrum5_001855, Phorbol acetate, myristate, CCRIS 716, MolMap_000041, UPCMLD-DP069

Molecular Formula:	C₃₆H₅₆O₈	Molecular Weight:	616.825040 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	8

InChIKey: PHEDXBVPIONUQT-RGYGYFBISA-N

• Phosgene Derivatives

• Phosphoric Acid Derivative

IUPAC Name: [(E,2S,3R)-2-azaniumyl-3-hydroxyoctadec-4-enyl] hydrogen phosphate

Molecular Formula:	C₁₈H₃₈NO₅P	Molecular Weight:	379.471782 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	5

InChIKey: DUYSYHSSBDVJSM-KRWOKUGFSA-N

• Phosphorus And Derivatives

• Phosphoserine antibodies

• Phthalylglycyl Chloride

IUPAC Name: 2-(1,3-dioxoisoindol-2-yl)acetyl chloride | CAS Registry Number: 6780-38-7
Synonyms: Phthalylglycyl chloride, Phthalimidoacetyl chloride, 636401_ALDRICH, N-PHTHALYLGLYCYL CHLORIDE, EINECS 229-840-8, CID81242, BRN 0183000, NSC401729, LS-84489, TL8004776, 2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-, 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride, 5-21-10-00440 (Beilstein Handbook Reference)

Molecular Formula:	C₁₀H₆ClNO₃	Molecular Weight:	223.612540 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	3

InChIKey: RHZBRCQIKQUQHQ-UHFFFAOYSA-N

• Pipecolic acid

IUPAC Name: piperidine-2-carboxylic acid | CAS Registry Number: 535-75-1
Synonyms: Homoproline, Pipecolinic acid, pipecolate, Dihydrobaikiane, l-Pipecolic acid, L-pipecolate, Piperolinic acid, homopipecolic acid, Hexahydropicolinic acid, Pipecolic acid, L-, L-Pipecolinic acid, 2-PIPERIDINECARBOXYLIC ACID, DL-Pipecolinic acid, .alpha.-Pipecolinic acid, Acide pipecolique [French], Pipecolic acid free base, Pipecolic acid, L-(-)-, Pipecolic acid, (S)-(-)-, pipecolic acid, ion (1-), NCIOpen2_001582

Molecular Formula:	C₆H₁₁NO₂	Molecular Weight:	129.157040 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	3

InChIKey: HXEACLLIILLPRG-UHFFFAOYSA-N

• Pipemidic acid

IUPAC Name: 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid | CAS Registry Number: 51940-44-4
Synonyms: pipemidic acid, Deblaston, Uromidin, Pipedac, Pipemid, Dolcol, Pipram, Palin, Spectrum_001387, Acido pipemidico [Spanish], Prestwick0_000897, Prestwick1_000897, Prestwick2_000897, Prestwick3_000897, Spectrum2_001185, Spectrum3_001487, Spectrum4_000155, Spectrum5_001214, Pipemidic acid [DCF:INN], Pipemidic acid [INN:DCF]

Molecular Formula:	C₁₄H₁₇N₅O₃	Molecular Weight:	303.316480 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	8

InChIKey: JOHZPMXAZQZXHR-UHFFFAOYSA-N

• Platinum (IV) Oxide

IUPAC Name: dioxoplatinum | CAS Registry Number: 1314-15-4
Synonyms: Platinium oxide, Platinic oxide, Platinum dioxide, Adam's catalyst, Adams' catalyst, Platinum(IV) oxide, PtO2, Platinium oxide, PtO2, Engelhard code S7018, Platinum oxide (PtO2), Platinum(IV) oxide hydrate, 206032_ALDRICH, 229059_ALDRICH, 459925_ALDRICH, 520616_ALDRICH, 520624_ALDRICH, NSC402624

Molecular Formula:	O₂Pt	Molecular Weight:	227.076800 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	2

InChIKey: YKIOKAURTKXMSB-UHFFFAOYSA-N

• Platinum alloys

• PMDM

IUPAC Name: 2,5-bis[2-(2-methylprop-2-enoyloxy)ethoxycarbonyl]terephthalic acid | CAS Registry Number: 83418-60-4
Synonyms: 1,4-Bis(2-((2-methyl-1-oxoallyl)oxy)ethyl) dihydrogen benzene-1,2,4,5-tetracarboxylate, AC1MD85Y, Ambcb5186359, SureCN4087259, CTK3E8882, MolPort-002-134-958, EINECS 280-452-5, 2,5-bis[2-(2-methylprop-2-enoyloxy)ethoxycarbonyl]terephthalic Acid, AG-H-33082, MCULE-4355110393, 1,2,4,5-Benzenetetracarboxylic acid, 1,4-bis(2-((2-methyl-1-oxo-2-propen-1-yl)oxy)ethyl) ester, 100552-00-9

Molecular Formula:	C₂₂H₂₂O₁₂	Molecular Weight:	478.402880 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	12

InChIKey: WKBYWKLXGWNHOB-UHFFFAOYSA-N

• Poly Propylene

IUPAC Name: 12-[(2S,3R)-3-octyloxiran-2-yl]dodecanoic acid | CAS Registry Number: 9003-07-0
Synonyms: 12-[(2s,3r)-3-octyloxiran-2-yl]dodecanoic acid, Oxiranedodecanoic acid, 3-octyl-, cis-, cis-13,14-Epoxydocosanoic acid, AC1L2S1O, AC1Q5W94, CTK5F2058, AR-1C0611, AG-K-28377, Oxiranedodecanoic acid, 3-octyl-, (2R,3S)-rel-, 2-Oxiranedodecanoic acid, 3-octyl-, (2R,3S)-rel-, 3420-36-8

Molecular Formula:	C₂₂H₄₂O₃	Molecular Weight:	354.567080 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	3

InChIKey: NSYDMBURIUSUDH-RTWAWAEBSA-N

• Poly(1,4-Butylene Adipate-Co-Polycaprolactam) (CAS: 66139-31-9)

• Poly(2,6-Dichlorostyrene) (CAS: 30350-14-2)

• Poly(2-Ethylacrylic Acid) (CAS: 62607-09-4)

• Poly(4-Vinylphenol-Co-Methyl Methacrylate) (CAS: 24979-71-3)

• Poly(4-Vinylpyridine)

IUPAC Name: 1,2-di(ethenyl)benzene; 4-ethenylpyridine | CAS Registry Number: 9017-40-7
Synonyms: Diethenylbenzene, polymer with 4-ethenylpyridine, Pyridine, 4-ethenyl-, polymer with diethenylbenzene, 178157-25-0

Molecular Formula:	C₁₇H₁₇N	Molecular Weight:	235.323580 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	1

InChIKey: HUEZUDXJCGHIHG-UHFFFAOYSA-N

• Poly(4-Vinylpyridine-Co-Butyl Methacrylate) (CAS: 53761-76-5)

• Poly(4-Vinylpyridinium P-Toluenesulfonate)

IUPAC Name: 4-(1,5-dipyridin-4-ylhexan-3-yl)pyridine;4-methylbenzenesulfonic acid | CAS Registry Number: 132759-93-4
Synonyms: Poly(4-vinylpyridinium p-toluenesulfonate)

Molecular Formula:	C₄₂H₄₇N₃O₉S₃	Molecular Weight:	834.032280 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	12

InChIKey: LSMFHWGJGDMHKB-UHFFFAOYSA-N

• Poly(Bis(1,4-Dioxapentyl)Phosphazene)

• Poly(Bis(1-(Ethoxycarbonyl)Methylamino)Phosphazene) (CAS: 79839-05-7)

• Poly(Bis(4-Carboxyphenoxy)Phosphazene)

• Poly(Dicyclopentadiene-Co-P-Cresol) Solid

Synonyms: none, EINECS 271-867-2, CID162222, LS-181776, Phenol, 4-methyl-, reaction products with dicyclopentadiene and isobutylene

Molecular Formula:	C₂₁H₂₈O	Molecular Weight:	296.446420 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	1

InChIKey: UQQYHXZNSYZMEN-UHFFFAOYSA-N

• Poly(Ethylene-Co-1-Butene-Co-1-Hexene)

IUPAC Name: but-1-ene; ethene; hex-1-ene | CAS Registry Number: 60785-11-7
Synonyms: 434752_ALDRICH, Poly(ethylene-co-1-butene-co-1-hexene), 1-Hexene, polymer with 1-butene and ethene, 162122-29-4, 179865-26-0

Molecular Formula:	C₁₂H₂₄	Molecular Weight:	168.318960 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	0

InChIKey: UOGXGYSMNPZLQN-UHFFFAOYSA-N

• Poly(Lauryl Methacrylate-Co-Ethylene Glycol Dimethacrylate)

IUPAC Name: dodecyl 2-methylprop-2-enoate; 2-(2-methylprop-2-enoyloxy)ethyl 2-methylprop-2-enoate | CAS Registry Number: 61181-29-1
Synonyms: Polytrap Q 5-6038, Polytrap Q 5-6603, 375012_ALDRICH, CID62178, Ethyl dimethacrylate - lauryl methacrylate copolymer, Dodecyl methacrylate - ethylene glycol dimethacrylate copolymer, Ethyl glycol dimethyacrylate - lauryl methacrylate copolymer, Poly(lauryl methacrylate-co-ethylene glycol dimethacrylate), Lauryl methacrylate, copolymer with ethylene glycol dimethacrylate, 143477-23-0, 2-Propenoic acid, 2-methyl-, dodecyl ester, polymer with 1,2-ethanediyl bis(2-methyl-2-propenoate)

Molecular Formula:	C₂₆H₄₄O₆	Molecular Weight:	452.623960 [g/mol]
H-Bond Donor:	0	H-Bond Acceptor:	6

InChIKey: YVUPJRVTTNZUEI-UHFFFAOYSA-N

• Poly(Styrene-Co-Chloromethylstyrene)

• Poly(Styrene-Co-Methacrylic Acid

IUPAC Name: 2,2-dimethyl-4-phenylhexanoic acid

Molecular Formula:	C₁₄H₂₀O₂	Molecular Weight:	220.312 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	2

InChIKey: ZUCGLGDTKCFKSN-UHFFFAOYSA-N

• Poly(Tetrahydrofurfuryl Methacrylate) (CAS: 25035-85-2)

• Poly(Vinylphosphonic Acid)

IUPAC Name: ethenylphosphonic acid | CAS Registry Number: 27754-99-0
Synonyms: Vinylphosphonic acid, 396311_ALDRICH, Phosphonic acid, ethenyl-, homopolymer, CID168725

Molecular Formula:	C₂H₅O₃P	Molecular Weight:	108.033061 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	3

InChIKey: ZTWTYVWXUKTLCP-UHFFFAOYSA-N

• Poly(Vinylpyridine)