Profile: Roche Applied Science is a developer of pharmaceutical drugs & healthcare products. We deal with pharmaceutical drugs, products for researchers, and solutions for diagnostics. Our anaprox (naproxen sodium) is used for the management of pain, fever, and inflammation. Our dormicum (midazolamhydrogenmaleat)is used for sedation as premedication given in advance of diagnostic or operative interventions.

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• Triphosphopyridine Nucleotide IUPAC Name: [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate | CAS Registry Number: 53-59-8 Synonyms: Codehydrase II, coenzyme II, Cozymase II, Nadide phosphate, Codehydrogenase II, NAD phosphate, TPN (nucleotide), beta-TPN, NADP, beta-NADP, TPN-ox, triphosphopyridine nucleotide, TPN+, CHEBI:44409, EINECS 200-178-1, CID5885, MolPort-003-939-771, nicotinamide adenine dinucleotide-P, BRN 3885115, nicotinamide adenine dinucleotide phosphate Molecular Formula: C21H28N7O17P3 Molecular Weight: 743.405003 [g/mol] H-Bond Donor: 8 H-Bond Acceptor: 21 InChIKey: XJLXINKUBYWONI-NNYOXOHSSA-N

• Urease (CAS: 9002-13-5)

• Uridine triphosphate IUPAC Name: [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate | CAS Registry Number: 63-39-8 Synonyms: uridine triphosphate, Uteplex, uridine 5'-triphosphate, H4utp, uridine-triphosphate, Uridine 5'-triphosphoric acid, 5'-UTP, Spectrum_001697, uridine-5'-triphosphate, Spectrum2_000525, Spectrum3_001596, Spectrum4_000851, Spectrum5_001167, INS365 Ophthalmic Solution, BSPBio_003192, KBioGR_001481, KBioSS_002177, DivK1c_000269, SPBio_000509, NChemBio.2007.9-comp22 Molecular Formula: C9H15N2O15P3 Molecular Weight: 484.141083 [g/mol] H-Bond Donor: 7 H-Bond Acceptor: 15 InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N

• 2-(N-Morpholino)Ethanesulfonic Acid IUPAC Name: 2-morpholin-4-ylethanesulfonic acid | CAS Registry Number: 4432-31-9 Synonyms: MES solution, MES hydrate, MOPS solution, MES (buffering agent), 4-Morpholineethanesulfonic acid, Morpholino-N-ethylsulfonate, 4-Morpholinethanesulfonic acid, Morpholineethanesulfonic acid, 1a7t, 2-(N-Morpholino)ethanesulfonic acid, Morpholinoethanesulfonic acid, 2-Morpholinoethanesulfonic acid, 2-Morpholinoethanesulphonic acid, Ethanesulfonic acid, 2-morpholino-, MLS000047669, M1317_SIGMA, M1442_SIGMA, M3671_SIGMA, 2-(4-Morpholinyl)ethanesulfonic acid, ARONIS023604 Molecular Formula: C6H13NO4S Molecular Weight: 195.236720 [g/mol] H-Bond Donor: 1 H-Bond Acceptor: 5 InChIKey: SXGZJKUKBWWHRA-UHFFFAOYSA-N

• 2-Pyridinol 1-oxide IUPAC Name: 1-hydroxypyridin-2-one | CAS Registry Number: 13161-30-3 Synonyms: Hydroxypyridinone, 2-Pyridinol-1-oxide, Hydroxyl-2-pyridone, 2-Pyridinol, 1-oxide, 1-Hydroxy-2-pyridone, pyridin-2-ol 1-oxide, 2-Hydroxypyridine 1-oxide, 2-Hydroxypyridine-N-oxide, NCIOpen2_003773, 1-hydroxypyridin-2(1H)-one, 56413_FLUKA, 2(1H)-Pyridinone, 1-hydroxy-, AIDS081859, AIDS-081859, EINECS 212-506-0, EINECS 236-100-8, NSC406972, SBB004329, SBB004330, ZINC00331625 Molecular Formula: C5H5NO2 Molecular Weight: 111.098700 [g/mol] H-Bond Donor: 1 H-Bond Acceptor: 2 InChIKey: SNUSZUYTMHKCPM-UHFFFAOYSA-N

• 5-Bromo-5-nitro-1,3-dioxane IUPAC Name: 5-bromo-5-nitro-1,3-dioxane | CAS Registry Number: 30007-47-7 Synonyms: Bronidox, 5-Bromo-5-nitro-m-dioxane, 1,3-Dioxane, 5-bromo-5-nitro-, B8791_SIGMA, EINECS 250-001-7, m-DIOXANE, 5-BROMO-5-NITRO-, 5-Brom-5-nitro-1,3-dioxan [German], BRN 4668673, ZINC02011293, LS-62273 Molecular Formula: C4H6BrNO4 Molecular Weight: 211.998740 [g/mol] H-Bond Donor: 0 H-Bond Acceptor: 4 InChIKey: XVBRCOKDZVQYAY-UHFFFAOYSA-N

• 2-Ketoglutaric acid IUPAC Name: 2-oxopentanedioic acid | CAS Registry Number: 328-50-7 Synonyms: 2-Oxopentanedioic acid, alpha-ketoglutaric acid, 2-oxoglutaric acid, 2-ketoglutaric acid, 2-oxoglutarate, 2-ketoglutarate, Oxoglutaric acid, alpha-ketoglutarate, ketoglutarate, Alphaketoglutaric acid, 2-oxopentanedionate, alpha-oxoglutarate, alpha-Oxoglutaric acid, alpha Ketoglutarate, Glutaric acid, alpha keto, 2-Oxo-Glutaric Acid, nchembio816-comp3, nchembio856-comp1, Glutaric acid, 2-oxo-, nchembio.145-comp9 Molecular Formula: C5H6O5 Molecular Weight: 146.098140 [g/mol] H-Bond Donor: 2 H-Bond Acceptor: 5 InChIKey: KPGXRSRHYNQIFN-UHFFFAOYSA-N

• 2-Chloroacetamide IUPAC Name: 2-chloroacetamide | CAS Registry Number: 79-07-2 Synonyms: Chloroacetamide, Microcide, Acetamide, 2-chloro-, Mergal AF, 2-Chloroethanamide, Chloracetamid, CHLORACETAMIDE, 2-Chloracetamide, .alpha.-Chloroacetamide, alpha-Chloracetamide, sJYHCaDIKTp@, Chloracetamid [German], USAF DO-29, WLN: ZV1G, C0267_SIGMA, ACETIC ACID,CHLORO,AMIDE, 22790_FLUKA, EINECS 201-174-2, HSDB 7449, NSC8408 Molecular Formula: C2H4ClNO Molecular Weight: 93.512260 [g/mol] H-Bond Donor: 1 H-Bond Acceptor: 1 InChIKey: VXIVSQZSERGHQP-UHFFFAOYSA-N

• 1-O-N-Octyl-Beta-D-Glucopyranoside IUPAC Name: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-octoxyoxane-3,4,5-triol | CAS Registry Number: 29836-26-8 Synonyms: B-Octylglucoside, Octyl glucoside, n-Octyl glucoside, Octyl beta-D-glucoside, nchembio828-comp13, beta-D-Octyl glucoside, Octyl-beta-D-glucoside, beta-Octyl monoglucoside, n-Octyl beta-D-glucoside, Octyl beta-glucopyranoside, 1-Octyl beta-D-glucoside, beta-D-Glucopyranoside, octyl, GLC-(1-1)OCT, OCTYL BETA-D-GLUCOPYRANOSIDE, O3757_SIGMA, 1-O-Octyl-beta-D-glucopyranoside, n-Octyl beta-D-glucopyranoside, 1-Octyl beta-D-glucopyranoside, O8001_SIAL, O9882_SIAL Molecular Formula: C14H28O6 Molecular Weight: 292.368520 [g/mol] H-Bond Donor: 4 H-Bond Acceptor: 6 InChIKey: HEGSGKPQLMEBJL-RKQHYHRCSA-N

• 5-Bromo-4-Chloro-3-Indolylphosphate IUPAC Name: (5-bromo-4-chloro-1H-indol-3-yl) dihydrogen phosphate | CAS Registry Number: 38404-93-2 Synonyms: Indole der., 5-Bcip, Fragment compound, 6, AIDS081053, AIDS-081053, CID65409, 5-Bromo-4-chloro-3-indoyl-phosphate, 5-Bromo-4-chloro-3-indolyl phosphate, 5-Bromo-4-chloro-3-indoxyl phosphate, 1H-Indol-3-ol, 5-bromo-4-chloro-, dihydrogen phosphate (ester) Molecular Formula: C8H6BrClNO4P Molecular Weight: 326.468301 [g/mol] H-Bond Donor: 3 H-Bond Acceptor: 4 InChIKey: QRXMUCSWCMTJGU-UHFFFAOYSA-N

• 6-Phosphogluconic Dehydrogenase (CAS: 9073-95-4)