Zison Pharmaceutical (Shandong) Co.,Ltd.

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Profile: Zison Pharmaceutical (Shandong) Co.,Ltd. specializes in manufacturing and marketing of high value added active pharmaceutical ingredients (APIs) and their intermediates. Our products include tenofovir alafenamide, safinamide, axitinib, lenvatinib, dacomitinib, avatrombopag, roxadustat and their intermediates. 1-Cyclohexylpiperazine is a key intermediate of the synthesis of avatrombopag.

9 Products/Chemicals (Click for related suppliers)

• Avatrombopag Impurity 8

IUPAC Name: 5-bromo-4-(4-chlorothiophen-2-yl)-1,3-thiazol-2-amine | CAS Registry Number: 2161380-87-4
Synonyms: 5-bromo-4-(4-chlorothiophen-2-yl)thiazol-2-amine, SCHEMBL19966961, AMY40538

Molecular Formula:	C₇H₄BrClN₂S₂	Molecular Weight:	295.600 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	4

InChIKey: NDDIDWDEBBDFIE-UHFFFAOYSA-N

• Benzamide, 2-Mercapto-N-Methyl-

IUPAC Name: N-methyl-2-sulfanylbenzamide | CAS Registry Number: 20054-45-9
Synonyms: 2-MERCAPTO-N-METHYLBENZAMIDE, N-methyl-2-sulfanylbenzamide, AC1NBZ0P, SureCN2829218, CTK8D3874, Benzamide, 2-mercapto-N-methyl-, AKOS000196042, KB-24825, AM20090683, FT-0690189

Molecular Formula:	C₈H₉NOS	Molecular Weight:	167.228160 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	2

InChIKey: VIFOAZNEQRHREM-UHFFFAOYSA-N

• DABRAFENIB MESYLATE

IUPAC Name: N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;methanesulfonic acid | CAS Registry Number: 1195768-06-9
Synonyms: Dabrafenib mesylate, UNII-B6DC89I63E, CHEBI:75048, GSK 2118436B, Dabrafenib mesylate (USAN), Dabrafenib mesylate [USAN], GSK 2118436, GSK-2118436, Tafinlar (TN), dabrafenib monomesylate, Dabrafenib methanesulfonate, METHANE SULFONATE SALT, B6DC89I63E, CHEMBL2105729, GSK2118436B, GSK-2118436A, GSK-2118436B, GSK2118436 Methane sulfonate salt, GSK2118436B, methane sulfonate salt, D10104

Molecular Formula:	C₂₄H₂₄F₃N₅O₅S₃	Molecular Weight:	615.668070 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	14

InChIKey: YKGMKSIHIVVYKY-UHFFFAOYSA-N

• Entrectinib (RXDX-101)

IUPAC Name: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide | CAS Registry Number: 1108743-60-7
Synonyms: Entrectinib, UNII-L5ORF0AN1I, L5ORF0AN1I, RXDX-101, Entrectinib [INN], N-(5-(3,5-Difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide, Kinome_2659, GTPL8290, NMS-E628, SCHEMBL3512601, CHEMBL1983268, HAYYBYPASCDWEQ-UHFFFAOYSA-N, S900006830, Benzamide, N-(5-((3,5-difluorophenyl)methyl)-1H-indazol-3-yl)-4-(4-methyl-1-piperazinyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-, N-[5-(3,5-Difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide

Molecular Formula:	C₃₁H₃₄F₂N₆O₂	Molecular Weight:	560.637466 [g/mol]
H-Bond Donor:	3	H-Bond Acceptor:	8

InChIKey: HAYYBYPASCDWEQ-UHFFFAOYSA-N

• Selpercatinib

IUPAC Name: 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile | CAS Registry Number: 2152628-33-4
Synonyms: CEGM9YBNGD, UNII-CEGM9YBNGD, Retevmo, 6-(2-Hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo(3.1.1)heptan-3-yl)pyridin-3-yl)pyrazolo(1,5-a)pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile, Retevmo (TN), Selpercatinib [INN], Selpercatinib [USAN], LOXO-292; Selpercatinib, Selpercatinib(LOXO-292), SCHEMBL20071478, Selpercatinib (JAN/USAN/INN), GTPL10318, BDBM296429, BCP29047, EX-A2859, s8781, WHO 10967, ZB1574

Molecular Formula:	C₂₉H₃₁N₇O₃	Molecular Weight:	525.600 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	9

InChIKey: XIIOFHFUYBLOLW-UHFFFAOYSA-N

• Tenofovir Alafenamide Fumarate

IUPAC Name: (E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate | CAS Registry Number: 1392275-56-7
Synonyms: Tenofovir Alafenamide fumarate, UNII-FWF6Q91TZO, Tenofovir Alafenamide fumarate [USAN], GS-7340-03, 1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate, (2E)-2-butenedioate, L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)

Molecular Formula:	C₄₆H₆₂N₁₂O₁₄P₂	Molecular Weight:	1069.004004 [g/mol]
H-Bond Donor:	6	H-Bond Acceptor:	24

InChIKey: SVUJNSGGPUCLQZ-ZFNQIRAGSA-N

• Tenofovir alafenamide hemifumarate

Molecular Formula:	C₄₆H₆₂N₁₂O₁₄P₂	Molecular Weight:	1069.004004 [g/mol]
H-Bond Donor:	6	H-Bond Acceptor:	24

InChIKey: SVUJNSGGPUCLQZ-ZFNQIRAGSA-N

• (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

IUPAC Name: (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide | CAS Registry Number: 1050477-31-0
Synonyms: Finerenone, UNII-DE2O63YV8R, CHEMBL2181927, DE2O63YV8R, SCHEMBL8157011, BAY 94-8862

Molecular Formula:	C₂₁H₂₂N₄O₃	Molecular Weight:	378.424380 [g/mol]
H-Bond Donor:	2	H-Bond Acceptor:	6

InChIKey: BTBHLEZXCOBLCY-QGZVFWFLSA-N

• 1-Cyclohexylpiperazine

IUPAC Name: 1-cyclohexylpiperazine | CAS Registry Number: 17766-28-8
Synonyms: 1-Cyclohexyl-piperazine, Oprea1_321928, EINECS 241-750-0, SBB003875

Molecular Formula:	C₁₀H₂₀N₂	Molecular Weight:	168.279200 [g/mol]
H-Bond Donor:	1	H-Bond Acceptor:	2

InChIKey: XPDSXKIDJNKIQY-UHFFFAOYSA-N